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C.STIM®, IPL SYSTEM 
FOR DRY EYE TREATMENT

IPL (Intense Pulsed Light) C.STIM® technology is a premium, safe and efficient IPL system dedicated to treat the root causes of dry eye disease.  This revolutionary IPL, specifically dedicated to Ophthalmic Uses, integrates patented homogeneous light and unique pulse train to offer the best combination of clinical efficacy and patient comfort. 

*Not FDA approved

Key Features

  • Treatment of the root causes of dry eye: MGD, inflammation, Demodex and neuropathic pain
  • Quick and easy treatment (<10 min)
  • Safe and efficient treatment thanks to the unique handpiece with an optical tip incorporating the Stim-ULI™ technology (Uniform Light Intensity) and the train of 5 regulated pulses.
  • Treatment on the majority of skin types thanks to the light spectrum, the train of 5 regulated pulses and to the water cooling of the handpiece.

Multiple mechanisms of action 
with C.STIM® IPL therapy

Meibomian Gland Dysfunction (MGD)

  • IPL speeds up Meibomian Gland and lacrimal gland metabolism by stimulating the parasympathetic nervous system thanks to the IPL energy stimulation.
     
  • IPL liquefies the thick meibum thanks to the heat generated by IPL light.
     
  • After IPL session, a manual meibomian gland expression, by pressing the tarsus with a meibomian forceps is important to increase the long-term effectiveness of IPL treatment and to relieve some signs and symptoms of Dry Eye.
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Inflammation

  • IPL stoppes the vicious cycle of chronic inflammation by coagulating new blood vessels of the skin and the eyelids, and by reducing inflammatory agents in the tears. 
     
  • The telangiectasias being smaller at the level of the eyelids, the IPL flash will have a localized heating effect at the level of the vessels and around the vessels. This effect modulates their function and changes their temperature.
     
  • Studies have shown that in cases of blepharitis, the number of telangiectasias in the eyelids decreased after IPL sessions.
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Demodex

  • Demodex is associated with facial and ocular rosacea. The parasite is a component of MGD, which is part of inflammatory vicious cycle.
     
  • Demodex Infestation leads to physical obstruction of meibomian glands and then causes obstructive meibomian gland dysfunction (MGD).
     
  • The pigmented exoskeleton of Demodex absorbs the energy of IPL leading to the Demodex destruction, and inflammatory markers are reduced.
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<p><br>An elegant design&nbsp;<br><strong>for ease of use</strong></p>


An elegant design 
for ease of use

With its large HD touch screen, C.STIM has an intuitive software with an access to the treatment page in 2 clicks.

It integrates pulse pre-settings dedicated to dry eye treatment to ensure safety and simplicity of use on the majority of skin types.

4 clinical strengths of C.STIM®

Take full advantage
with a wide range of accessories

Patient protective shells
Meibomian forceps
C.STIM trolley
Patient protective intraocular scleral shell
Practitioner protective goggles
Patient disposable protection patch

Testimonials

How to include the C.STIM® IPL
in your therapeutic arsenal?


IPL is now part of the therapeutic arsenal for dry eye
Review the case study below to learn how it can be used to complement other dry eye treatments.
 

KLINISKE EKSEMPLER FRA VÅRE EKSPERTER

Fordi pasientbehandling er kjernen i vårt engasjement, er det viktig å samle erfaringene til leger som bruker produktene våre.

Tilgang til alle våre kliniske caser

Model still available in some countries according to local registration: LacryStim
For further information, please contact us.


C.STIM® and Stim-ULI™ are trademarks of Quantel Medical and Lumibird Medical.
All rights reserved.


Bibliography :

1. Parasympathetic Innervation of the Meibomian Glands in Rats – Mark S. LeDoux et al. – Investigative Ophthalmology & Visual Science, October 2001, Vol. 42, No. 11.
2. Characterization of the innervation of the meibomian glands in humans, rats and mice – Bründl, M. et al. Annals of Anatomy (2021), Vol. 233.
3. Neurotransmitter Influence on Human Meibomian Gland Epithelial Cells – Wendy R. Kam and David A. Sullivan – Investigative Ophthalmology & Visual Science, November 2011, Vol. 52, No. 12.
4. The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease – Ji, Yong Woo et al. Investigative Ophthalmology & Visual Science (2021), Vol. 62.
5. TFOS DEWS II Pathophysiology Report – Anthony J. Bron, et al. – The Ocular Surface, 2017, p 441 to 515.
6. The neurobiology of the meibomian glands – Cox SM, Nichols JJ – Ocular Surface, July 2014.
7. Multicenter Study of Intense Pulsed Light Therapy for Patients with Refractory Meibomian Gland Dysfunction – Reiko Arita, et al. – Cornea Volume 37, Number 12, December 2018.
8. Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition – Yu Ri Woo, et al. International Journal of Molecular Sciences, September 2016.
9. Rosacea: Epidemiology, pathogenesis, and treatment – Barbara M. Rainer et al. – DERMATO-ENDOCRINOLOGY 2018, VOL. 9, NO. 1, e1361574 (10 pages).
10. Treatment of ocular rosacea – Edward Wladis et al. – Survey of Ophthalmology (2018), Vol. 63.
11. Improved telangiectasia and reduced recurrence rate of rosacea after treatment with 540 nm-wavelength intense pulsed light: A prospective randomized controlled trial with a 2-year follow-up – Luo, Y. et al. – Experimental and Therapeutic Medicine (2020), Vol. 19.
12. Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis – Zhang, X., et al. – Current Eye Research 2019, Vol. 3.
13. Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation – Cheng et al. – Current Medical Sciences (2019), Vol. 39.
14. Long-term effects of intense pulsed light treatment on the ocular surface in patients with rosacea-associated meibomian gland dysfunction – Seo Kyoung Yul et al. – Contact Lens and Anterior Eye (2018), Vol. 41.
15. TFOS DEWS II Tear Film Report – Willcox Mark et al. – The Ocular Surface (2017), Vol. 15.
16. Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction – Vigo, L. et al. – Journal of Visualized Experiment (2019), N°146.
17. Meibum Expressibility Improvement as a Therapeutic Target of Intense Pulsed Light Treatment in Meibomian Gland Dysfunction and Its Association with Tear Inflammatory Cytokines – Choi, M. et al. – Scientific Reports (2019), Vol. 9.
18. TFOS DEWS II Pain and Sensation Report – Belmonte Carlos, et al. – The Ocular Surface (2017), Vol. 15.
19. Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction – LIU, R et al. – American Journal of Ophthalmology (2017).
20. Effect of inflammation on lacrimal gland function – Driss Zoukhri – Experimental Eye Research, May 2006; 82(5): 885–898.
21. Aqueous deficiency is a contributor to evaporation-related dry eye disease – Charles W. McMonnies – Eye and Vision (2020) 7:6.
22. A retrospective study of the efficacy of intense pulsed light delivered by the Lacrystim® for meibomian gland dysfunction therapy - Marie‑Caroline Trone et al. - BMC Ophthalmology (2022) 22:335

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